全文获取类型
收费全文 | 2549篇 |
免费 | 147篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 50篇 |
妇产科学 | 20篇 |
基础医学 | 362篇 |
口腔科学 | 49篇 |
临床医学 | 135篇 |
内科学 | 615篇 |
皮肤病学 | 48篇 |
神经病学 | 130篇 |
特种医学 | 138篇 |
外科学 | 355篇 |
综合类 | 10篇 |
预防医学 | 39篇 |
眼科学 | 85篇 |
药学 | 202篇 |
中国医学 | 2篇 |
肿瘤学 | 442篇 |
出版年
2023年 | 16篇 |
2022年 | 15篇 |
2021年 | 32篇 |
2020年 | 23篇 |
2019年 | 42篇 |
2018年 | 53篇 |
2017年 | 40篇 |
2016年 | 51篇 |
2015年 | 36篇 |
2014年 | 58篇 |
2013年 | 72篇 |
2012年 | 83篇 |
2011年 | 141篇 |
2010年 | 77篇 |
2009年 | 57篇 |
2008年 | 100篇 |
2007年 | 120篇 |
2006年 | 143篇 |
2005年 | 102篇 |
2004年 | 129篇 |
2003年 | 121篇 |
2002年 | 127篇 |
2001年 | 98篇 |
2000年 | 110篇 |
1999年 | 83篇 |
1998年 | 43篇 |
1997年 | 31篇 |
1996年 | 19篇 |
1995年 | 21篇 |
1994年 | 22篇 |
1993年 | 16篇 |
1992年 | 61篇 |
1991年 | 62篇 |
1990年 | 66篇 |
1989年 | 72篇 |
1988年 | 39篇 |
1987年 | 36篇 |
1986年 | 49篇 |
1985年 | 35篇 |
1984年 | 32篇 |
1983年 | 28篇 |
1981年 | 14篇 |
1980年 | 14篇 |
1979年 | 22篇 |
1978年 | 7篇 |
1974年 | 7篇 |
1973年 | 9篇 |
1972年 | 8篇 |
1971年 | 8篇 |
1967年 | 10篇 |
排序方式: 共有2708条查询结果,搜索用时 15 毫秒
21.
Yuuka Mukai Yongkun Sun Shin Sato 《Nutrition (Burbank, Los Angeles County, Calif.)》2013,29(1):291-297
ObjectiveFetal malnutrition is an early-life inducer of dyslipidemia and glucose intolerance. The aim of this study was to examine whether maternal azuki bean (Vigna angularis) polyphenol (AP) intake during lactation affects the adenosine monophosphate–activated protein kinase (AMPK) pathway and lipid metabolism in offspring exposed to fetal malnutrition.MethodsPregnant Wistar rats were divided into three groups: a control diet offered during gestation and lactation (CC), a low-protein diet during gestation and a control diet during lactation (LPC); and a low-protein diet during gestation and a 1.0% AP-containing control diet during lactation (LPAP). Male pups were randomly selected for the study; half the pups were sacrificed at 3 wk of age and the other half were fed a standard diet and sacrificed at 23 wk. Hepatic triacylglycerol levels, phosphorylation levels of AMPK and acetyl-coenzyme A carboxylase (ACC), and mRNA levels of sterol regulatory element-binding protein-1c (SREBP-1c) were evaluated.ResultsSignificant decreases in body weights and hepatic triacylglycerol levels were found in the LPAP compared with the LPC group. Plasma adiponectin levels in the LPAP group were higher than those in the LPC group. AMPK phosphorylation was upregulated in the livers and skeletal muscles in young and adult LPAP compared with LPC rats. ACC phosphorylation was upregulated in skeletal muscles of LPAP rats. SREBP-1c mRNA expression was decreased in the livers of LPAP rats.ConclusionOur results suggest that maternal AP intake during lactation upregulates AMPK phosphorylation not only in young but also in adult offspring exposed to fetal malnutrition and may lead to decreased hepatic lipid accumulation by ACC phosphorylation and downregulation of SREBP-1c expression. 相似文献
22.
23.
Multiple primary syphilis on the lip,nipple–areola and penis: An immunohistochemical examination of Treponema pallidum localization using an anti‐T. pallidum antibody 下载免费PDF全文
Hidetsugu Fukuda Misaki Takahashi Keiichi Kato Toshiaki Oharaseki Hideki Mukai 《The Journal of dermatology》2015,42(5):515-517
Primary syphilis caused by Treponema pallidum usually develops after sexual contact as an initial solitary sclerosis or hard chancre in the genital region. We describe a case of primary syphilis at three sites in genital and extragenital regions of a man who had sex with men. A 29‐year‐old man visited our hospital for skin lesions on his lower lip, nipple–areola and penis. A positive syphilis serological test for rapid plasma reagin had a titer of 1:16; the patient also tested positive for specific antibodies against T. pallidum, with a cut‐off index of 39.0. Histopathological examination of a nipple–areola biopsy specimen revealed a thickened epidermis and dense infiltration of inflammatory cells extending from the upper dermal layers to the deep dermis. The inflammatory cells were composed of abundant lymphocytes, plasma cells, histiocytes and neutrophils. Immunohistochemical staining for T. pallidum using an anti‐T. pallidum antibody showed numerous spirochetes in the lower portion of the epidermis, scattered inside inflammatory cell infiltrate and perivascular sites throughout the dermis. Based on these findings, the patient was diagnosed with primary syphilis. Treatment with oral amoxicillin hydrate was started. Five days after starting treatment, a diffuse maculopapular rash (syphilitic roseola) occurred on his trunk and extremities. Perivascular cuffing due to T. pallidum was present throughout the dermis in the biopsy specimen of a localized lesion of primary syphilis. Moreover, syphilitic roseola, which indicates generalized dissemination of T. pallidum, developed during the course of treatment for primary syphilis. Therefore, we considered perivascular cuffing to be indicative of the dissemination phase. 相似文献
24.
Takeshiro Fujii Muneyasu Kawasaki Tomoyuki Katayanagi Shinnosuke Okuma Hiroshi Masuhara Noritsugu Shiono Yoshinori Watanabe 《Annals of thoracic and cardiovascular surgery》2015,21(6):570-573
A 52-year-old male patient with a history of total arch replacement using the elephant trunk technique for acute aortic dissection 4 years before visited our hospital with the chief complaint of persistent fever. Chest computed tomography (CT) suggested prosthetic vascular graft infection, which was treated surgically after chemotherapy. The first surgery consisted of debridement of an abscess around the vascular graft and in the aorta around the elephant trunk, and thoracic descending aorta replacement and vacuum-assisted closure (VAC) in view of the risk of bleeding from the peripheral region of the elephant trunk. One week later, omental filling was performed as the second step. This is a very rare case of aortic abscess around the elephant trunk that could successfully be managed by graft-conserving treatment. 相似文献
25.
26.
Pradeep Natarajan Tim S. Collier Zhicheng Jin Asya Lyass Yiwei Li Nasrien E. Ibrahim Renata Mukai Cian P. McCarthy Joseph M. Massaro Ralph B. D’Agostino Hanna K. Gaggin Cory Bystrom Marc S. Penn James L. Januzzi 《Journal of the American College of Cardiology》2019,73(17):2135-2145
Background
Concentrations of circulating apolipoproteins are strongly linked to risk for coronary artery disease (CAD). The relative importance of the additional knowledge of apolipoprotein concentrations within specific lipoprotein species for CAD risk prediction is limited.Objectives
This study sought to evaluate the performance of a high-density lipoprotein (HDL) apolipoproteomic score, based on targeted mass spectrometry of HDL-associated apolipoproteins, for the detection of angiographic CAD and outcomes.Methods
HDL-associated apolipoprotein (apo) A-1, apoC-1, apoC-2, apoC-3, and apoC-4 were measured in 943 participants without prevalent myocardial infarction (MI) referred for coronary angiography in the CASABLANCA (Catheter Sampled Blood Archive in Cardiovascular Diseases) study. A composite HDL apolipoproteomic score (pCAD) was associated with likelihood of obstructive CAD (≥70% lesion in ≥1 vessel) and with incident cardiovascular outcomes over 4-year follow-up.Results
There were 587 (62.2%) patients with coronary stenosis. The pCAD score was associated with the presence of obstructive CAD (odds ratio: 1.39; 95% confidence interval [CI]: 1.14 to 1.69; p < 0.001), independently of conventional cardiovascular risk factors including circulating plasma apoA-1 and apoB. The C-index for pCAD was 0.63 (95% CI: 0.59 to 0.67) for the presence of obstructive CAD. Although pCAD was not associated with cardiovascular mortality among all individuals (hazard ratio: 1.24; 95% CI: 0.93 to 1.66; p = 0.15), there was evidence of association for individuals with obstructive CAD (hazard ratio: 1.48; 95% CI: 1.07 to 2.05; p = 0.019).Conclusions
An HDL apolipoproteomic score is associated with the presence of CAD, independent of circulating apoA-1 and apoB concentrations and other conventional cardiovascular risk factors. Among individuals with CAD, this score may be independently associated cardiovascular death. (The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA]; NCT00842868) 相似文献27.
Eri Tarumi Yasuaki Nakagawa Shogo Mukai Hiromitsu Yabumoto Takashi Nakamura 《Journal of orthopaedic science》2019,24(1):136-141
Background
There have been some reports of high tibial osteotomy combined with osteochondral autograft transfer for osteonecrosis of the medial femoral condyle of the knee. However, few of them have focused on the deep knee flexion needed to sit straight in the Japanese style.Purpose
To evaluate the clinical outcomes and the knee flexion of HTO combined with OAT for osteonecrosis of the medial femoral condyle of the knee, especially the ability to sit straight in the Japanese style.Methods
Between 1998 and 2012, valgus HTO combined with OAT was performed in 23 patients for stage IV osteonecrosis according to Koshino's radiological classification of the medial femoral condyle. The follow-up period was more than 2 years in all cases. The mean age at the time of the surgery was 65.8 years, and the mean follow-up period was 72.2 months. The function of the knee and the ability to sitting straight in the Japanese style were examined. Twenty-one knees were examined with second-look arthroscopy to assess the recipient and donor sites.Results
The JOA scale and IKDC subjective scores were significantly improved. Twelve patients were able to sit straight in the Japanese style after the surgery, compared to 3 patients who were able to do so before surgery. On second-look arthroscopy of 21 knees, the average ICRS score was 10.5 points. No patient needed additional surgery except for removal of the implants.Conclusion
Valgus HTO combined with OAT is one treatment option for osteonecrosis of the medial femoral condyle with osteoarthritis. In the present study, many of the patients regained good knee function, and 50% of the patients were able to sit straight in the Japanese style after surgery, which is a higher rate than after total knee arthroplasty and unilateral knee arthroplasty. 相似文献28.
Low‐grade intraductal carcinoma of the salivary gland with prominent oncocytic change: a newly described variant 下载免费PDF全文
29.
CIC break‐apart fluorescence in‐situ hybridization misses a subset of CIC–DUX4 sarcomas: a clinicopathological and molecular study 下载免费PDF全文
30.
Incidence of gastric adenocarcinoma among lesions diagnosed as low‐grade adenoma/dysplasia on endoscopic biopsy: A multicenter,prospective, observational study 下载免费PDF全文